n cosmetic medicine, regenerative treatments have the potential for transformative results. Many clinics opt for artificially induced methods to stimulate stem cell division, often using synthetic materials that can carry unpredictable risks.

Dr. Hiroo Kuno, founder of Kuno Clinic, redefines what is possible in rejuvenation treatments. In 2007, he introduced the concept of in vivo regenerative medicine, a groundbreaking approach that as of 2025 remains unmatched by any other technology in the world. Classic facelift procedures, which require excision and are prone to visible scarring and nerve palsies, do not offer long-term effectiveness and can result in an unnatural facial appearance. Similarly, lift thread insertion procedures offer only short-term results and are no longer necessary.

The clinic embraces a natural, regenerative approach to aesthetic plastic surgery. It uses the patient’s adipose tissue, fat-derived stem cells and platelet-rich plasma(PRP), combined with a curated blend of vitamins, amino acids and essential nutrients(PRM =premium nutrition) to promote true tissue regeneration.

These stem cells grow and differentiate controllably and naturally within the body, promoting biocompatible healing and minimizing the risk of side effects. After surgery, additional injections of PRP and PRM can be used to increase tissue volume in vivo, and by filling in recurrent wrinkles, it provides semi-permanent results.

“Because every face and body is unique, we match every detail with the best techniques to best suit your individual goals and specific needs,” says Dr. Kuno.

The flagship in vivo regenerative method delivers exceptional results in high-demand areas, including the face, neck, décolleté, breasts, buttocks and hands.

Adopting a fully customized approach, Kuno Clinic designs treatment plans that reflect each patient’s goals. Dr. Kuno oversees every step from consultation to procedure and aftercare, ensuring an attentive, hands-on experience. His principles emphasize minimizing the use of scalpels, reducing incisions and tissue removal and avoiding potentially harmful foreign substances such as silicone implants or FGF-based products. The focus is always on safety, harmony and achieving natural results. Even the subtlest enhancements, like the way a smile appears, are executed with extraordinary precision using his signature 4D aesthetic techniques. His same-day outpatient approach minimizes downtime, making advanced aesthetic care more accessible.

In 2006, when facial rejuvenation was mostly limited to facelifts or noninvasive treatments, Dr. Kuno emerged as a trailblazer by systematically classifying the diverse and often inconsistent thread lift techniques, which was published in a medical journal.

He developed a clear framework outlining indications, efficacy, risks, design variations and insertion methods. With his analytical perspective, he quickly identified the limitations of these procedures, including contraindications, non-absorbable threads, variations in practitioner skill and the inherent limits of treatment longevity.

In 2009, in pursuit of more effective solutions beyond thread lifting, Dr. Kuno became one of the first five Japanese surgeons certified in advanced body contouring by the VASER Hi Def Institute in the U.S. Although the program focused solely on body design techniques and did not include facial liposuction or regenerative applications, he expanded its scope by adapting VASER technology for facial use. By commissioning a custom facial cannula from a Japanese engineer, he developed a proprietary in-clinic method that ensures sub-millimeter precision and remarkably natural results.

Building on the core principles behind VASER, Dr. Kuno has since developed the world’s most extensive portfolio of advanced adaptations. These include non-excisional techniques for sagging breasts, innovative therapies for lymphedema and corrective procedures for patients unhappy with previous liposuction results. His mastery of ultrasound calibration and suction dynamics enables him to accurately tailor each procedure, ensuring minimal trauma to harvested cells. This is a critical factor in both aesthetic refinement and revitalization of the craftsmanship of the master.

Rooted in groundbreaking innovation, clinical excellence and patient-first values, Kuno Clinic continues to set new standards in aesthetic care, transforming the future of beauty and wellness.